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Slide Are you genetically
predisposed
to premature
wrinkling?
Are you genetically
predisposed to
premature wrinkling?
Discover Today SkinDNA® Genetic Test

Slide Are you genetically
predisposed
to premature
wrinkling?
Are you genetically
predisposed to
premature wrinkling?
SkinDNA® Genetic Test

Category Two

Glycation Wrinkling

If you’re like most people, then no one has ever told you about glycation. Glycation has been described as carmelization of the skin from the inside out.

Affecting Collagen and Elastin fibers, glycation is now well recognized to be a leading cause of accelerated skin aging. Key genetic markers tested in this genetic category play a key role in preventing glycation of your skin.

What your genes have to do with it

The role of genetics

The genes that make up your Wrinkling (A.G.E.) score play a key role in skin Glycation. They are responsible for controlling serum glucose levels, energy intake and energy release.

Having variations in these genes can alter the functioning of normal glucose levels and energy metabolism. While glucose is a vital cellular fuel, if not completely metabolized by the body Glycation can occur, leading way to wrinkling, dryness and laxity.

What genes are tested?

Glycation Interruption

Responsible for controlling serum glucose levels, energy intake and release. While glucose is a vital cellular fuel, if not fully metabolised Glycation can occur.

Did you know?

1 in 2

Are genetically predisposed to reduced genetic protection against Glycation.

Did you know?

1 in 2

1 in 2

Are genetically predisposed
to reduced genetic protection
against Glycation.

How does skin glycation happen?

Sugar and Wrinkles

Glucose is the sugar your body uses as its main source of fuel. If not metabolized properly, glucose can bind to your skin’s collagen and elastin fibers, forming abnormal chemical bridges that cause tissue damage. This process, called glycation, causes your skin to become rigid and lose elasticity.

Glycation also impairs your skin’s ability to regenerate, which leads to skin laxity, cracking, thinning, redness and inability to self-repair.

Young Skin
The dermal junction has the appearance of a mountain range that helps anchor the Epidermis to the Dermis, forming a network of supportive Collagen fibers.
Aging Skin
As your skin ages these supportive fibers—which are responsible for the appearance and texture of your skin, lose their supportive network as a result of glycation.

Sugar and Wrinkles

Glucose is the sugar your body uses as its main source of fuel. If not metabolized properly, glucose can bind to your skin’s collagen and elastin fibers, forming abnormal chemical bridges that cause tissue damage. This process, called glycation, causes your skin to become rigid and lose elasticity.

Glycation also impairs your skin’s ability to regenerate, which leads to skin laxity, cracking, thinning, redness and inability to self-repair.

Collagen Balance​
Genetic abnormalities can lead to an increased rate of collagen breakdown1.
Collagen Imbalance​
Genetic abnormalities can lead to an increased rate of collagen breakdown1.

.

Young Skin
The dermal junction has the appearance of a mountain range that helps anchor the Epidermis to the Dermis, forming a network of supportive Collagen fibers.
Aging Skin
In aging skin these fibers responsible for the appearance and texture of your skin, lose their supportive network causing wrinkles.

Background Science

About Glycation

Causing Collagen and Elastin fibers to lose their ability to function normally, glycation is implicated in accelerated skin aging.

Glycation has been described as carmelization of the skin from the inside out. The skin-damaging effects of glycation cause wrinkles, dryness (eczema), skin laxity, as well as acne and rosacea.

Advanced Glycation End Products (A.G.Es) are the end result of a glucose-driven process known as Glycation. Glycation occurs when excess bodily glucose molecules link to the skin’s Collagen and Elastin fibers.

This cross-linking can form chemical bridges between these proteins. Glycated fibers can become rigid, less elastic and have reduced regenerative ability, which can lead to damage such as laxity, cracking and thinning skin.

Skin Glycation

Glycated wrinkles are a result of hardened elastin fibers and these types of wrinkles appear around the eyes, cheeks and chin areas.

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Skin Glycation

Glycated wrinkles are a result of hardened elastin fibers and these types of wrinkles appear around the eyes, cheeks and chin areas.

Next Category

Sun Damage & Pigmentation

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