1. Firmness + Elasticity
2. Wrinkling (A.G.E.)
3. Sun Damage + Pigmentation
4. Free Radical Damage
5. Sensitivity + Inflammation
Category 1
Firmness + Elasticity
COLLAGEN IS AN IMPORTANT ELEMENT OF HUMAN SKIN, IN FACT IT IS THE PRINCIPLE STRUCTURAL PROTEIN HOLDING THE SKIN TOGETHER.
The genes in this category are involved in slowing the breakdown and degradation of Collagen Fibers found in the extracellular matrix of human tissue. Key variations tested in this category can identify if the synthesis and degradation process of Collagen is in balance, or if the degradation predominates (increased MMP levels) that can result in the appearance of premature wrinkling, loss of youthful looks and other ageing skin traits.
DID YOU KNOW
1 in 3 people have a genetic variation that predisposes their skin to accelerated wrinkling.
It is well established that Collagen is an important element of human skin1; in fact it is the principle structural Protein holding the skin together. Representing 75% of the skin's dry weight2 it keeps the skin firm, plump and wrinkle-free. The quantity and quality of the Collagen plays a major role in the skin's appearance. Like many components of the body, Collagen undergoes continuous turnover: new Collagen is continually produced and recycled throughout life.
At a younger age, the synthesis of Collagen predominates, whereas after about the age of 40, the degradation of Collagen picks up speed .4 This degradation process is precipitated by a protein called Matrix Metallopeptidase-1 (MMP's) or Collagenase. As we age our bodies struggle to replenish stores of collagen, and some people are genetically primed to break down collagen faster than others.
In healthy, youthful skin, the synthesis and degradation of Collagen is in balance: damaged or redundant Collagen is degraded while the deficit is replenished by the ongoing synthesis4. Unfortunately, this intricate balance gets disrupted when there is an oversupply of MMP1: too little of the matrix is synthesized and too much is degraded .1,3 The more this occurs the more winkles, roughness and sagginess one tends to have. MMP levels are known to increase with age as a result of photo aging5 as well as natural aging .3,4
Gene Table
| SkinDNA™ Gene Descriptor |
Genotype |
Description |
s700298/
Collagen Stimulation |
1G1G |
Involved in slowing the breakdown and degradation of Collagen fibers found in the extracellular matrix of human tissue.
Chromosome Location: 11q21-q22 |
s706371/
Glutathione Production |
TT |
Normalises skin cell functions disrupted by oxidative stress including MMP-1 production
Chromosome Location: 3q21.3 |
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